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There are several things that can be done to mitigate noise in digital images.
First: Do not underexpose. Shadow areas pulled back from the dark in post processing will show excessive noise even at low ISO. Try overexposing 1/2 stop or so. Check your histogram to make sure you're not blowing your whites out when you do this.
To some extent you can choose which part of your sensor's dynamic range you want to use - expose to the right of the histogram and you'll avoid noise but may lose some highlights. Expose to the left and you'll retain all your highlights but have noisy ugly shadows. If you are shooting from a tripod you can get the best of both worlds by exposure bracketting and combining to form a HDR image in post.
Second: Apart from these in-camera strategies there is some very effective noise reduction software available today. I personally like Neat Image or Noise Ninja, but there are lots of packages that work quite well. Don't go hog wild with noise filtering or you'll start to lose image detail, but you can do quite a lot toward suppressing image noise once you get comfortable with one of these programs.
best of luck
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